Since the PowerZone Broadleaf Herbicide is not labeled for use on any kind of Buffalo grass, we would not recommend applying it to your turfgrass. If you already have this product, then we would suggest testing an inconspicuous area first at the lowest rates to check turf tolerance. This is usually recommend anytime you are using a new product on a hybrid kind of turfgrass since it is unlikely that most products will have been tested on those turfgrasses