Cyzmic CS would be a good choice for general insect control and spider control. Even though Brown Recluse spiders are very scary to have in your house they are no harder to get rid of than any other spider. The hardest part of getting rid of the brown recluse is finding them since they like to remain hidden. Cyzmic CS would be a great choice for indoor and outdoor spider control. Spraying Cyzmic CS will also help to get rid of the insects (silverfish, sow bugs aka rollie pollies and millipedes) that spiders feed on and that will help to stop new spiders from moving in. Indoors, spray around all baseboards, door frames, window frames, under appliances, in closets and storage rooms and in areas where utilities enter into the structure. Outdoors you should spray around the bottom of the foundation, on the ground adjacent to the foundation, door frames, window frames and places where the utilities enter into the structure. As for the mold or bacteria you have noticed, this problem would need to be treated with a different product. Boracare with Moldcare can be used to treat mold and certain wood fungus on unfinished wood. If you have a mold/bacteria problem in other areas you would need to contact a professional.