Pramitol 25E is not labeled for use around or near water wells. Per the product label, this chemical has properties and characteristics associated with chemicals detected in groundwater. The use of this chemical in areas where soils are permeable, particularly where the water table is shallow, may results in groundwater contamination. Application around a cistern or well may result in contamination of drinking water or groundwater.
The Pramitol 25E has such a long soil residual that you can't really predict how far it may move so would not be advised to apply around anything desirable nor around edibles.
When using Pramitol 25E Herbicide, you actually want it to rain. This product will not provide herbicidal action in the treated area unless application is immediately followed by watering the area with at least ¼" of water or application of the product just prior to a rain event sufficient to penetrate to the root system of the target vegetation.
You only want to mix up what you plan to use at a time and not keep it stored in a tank sprayer for more than 24-48 hours max if you want it to carry the same potency. Products like Pramitol 25E, if used correctly should only have to be reapplied every year so if you are finding you are having to treat more frequently in areas you used it in, we would suggest using a little higher ratio per 1000 sq/ft and use a higher water volume over that whole area to ensure it is getting deep enough in the soil to set up an adequate long lasting barrier.
There is no restriction on the Pramitol 25E product label regarding playgrounds, it would be used only in areas where complete control of all vegetation is desired. As long as children are out of the area during application until dry it should be ok to use.
Yes, Pramitol 25E can be mixed with glyphosate products like Cornerstone Plus Herbicide for more effective results.