Frontline Plus For Cats

5 out of 5 stars 2 Reviews | 12 Q&A

Frontline Plus For Cats
Frontline Plus For Cats

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Average Rating

5 out of 5 stars Rating: 5

2 Reviews | 12 Q&A

Product Overview

Frontline Plus For Cats has a combination of two active ingredients that works together to regulate and eliminate fleas. Fipronil and (s)-methoprene fights fleas and ticks by migrating all over the cat's body through translocation within 24 hours. The pet's oil glands beneath the skins act as a storage where Frontline Plus is continuously active on the skin's surface. The solution works by attacking the nerve cells of ticks and fleas, making them hyper and disoriented before dying. (S)-methoprene works by preventing any egg production and hatching of fleas. It also helps in prohibiting larval development. The waterproof formula of the product serves as a long lasting protection for cats and is rapidly distributed to effectively kill most major species of ticks.


  • Fast-acting
  • Long-lasting
  • Waterproof

Each box contains a 3 month supply. For cats 8 weeks and older. Each application last for 30 days. Only apply once every 30 days.

Product Documents

Features and Specs

Active Ingredient Fipronil - 9.8% (s)-methoprene - 11.8%
Target pests Fleas and Ticks
For use in Cats (over 8 weeks old)
Application One (1) pipette of 0.5 ml per cat (up to 8 kg)
Pet safe Yes, if used as directed on label
Special Features In a recent study, it was shown that the powerful ingredients of FRONTLINE Plus work to kill adult fleas within 12 hours of application.
* They then go on to break the flea life cycle by destroying the next generation of fleas.
* Its long-lasting formula is stored in the oil glands of the cat's skin to give non-stop flea and tick protection for a full 30 days.
Shipping Weight 0.10 lbs
Manufacturer Merial (Mfg. Number: 287410)
EPA Registration 65331-4


Follow these instructions to apply Frontline Plus.

To apply, simply follow these instructions–and repeat every 30 days:

  • Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open.
  • Open Applicator: Hold upright with foil side toward you and snap applicator tip.
  • Apply FRONTLINE Plus: Part your pet's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry.

Here are some additional tips.

  • Remove the pet's collar
  • Apply as a spot between your pet's shoulder blades in 1 area that can't be licked
  • Avoid touching the wet application spot
  • Wait 24 hours to allow solution to dry before bathing or letting your pet swim
  • Give each of your pets its own complete dose

Don't forget to reapply every 30 days.

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Sort Reviews
  • 5 of 5 Stars

    Frontline plus for cats

    By Wanda on 09/06/2015

    Works well on all 3 cats. Service is good with prompt delivery.

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    10 of 11 people found this review helpful

  • 5 of 5 Stars

    Frontline Plus for Cats

    By Cathy on 04/17/2020

    I was using a different brand for almost 6 months and could not get rid of all the fleas. Used this 1 time and I haven't seen any on our cat.

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    7 of 7 people found this review helpful

See all 2 customer reviews

Questions & Answers

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Sort Questions
Is Frontline Plus for Cats safe to use when multiple cats are inside and wash each other?

Yes, Frontline Plus for Cats is for use directly on the cat in the area between the shoulder blades behind the neck of each cat. Most cats will not notice anything different in those areas to target cleaning there more than normal, however, keeping the cats separated for a little bit until the products has had some time to absorb into their skin and dry would be preferred.

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43 of 48 people found this answer helpful

Can I bathe my cat after administering Frontline?

I'd like to give my cat a bath to remove dead fleas and flea dirt. How long should I wait after applying Frontline?


Frontline Plus For Cats remains effective even after bathing, water immersion, or exposure to sunlight. However, we recommend waiting until the product has had some time to absorb into their skin and dry prior to bathing. Since this product is oily it could take a few hours to dry. 

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42 of 52 people found this answer helpful

Is it safe to put Frontline Plus on my cat now while the kittens are nursing?

My cat had kittens 9 days ago.


Frontline Plus For Cats does state on the product label:  Approved for use on all cats, including breeding, pregnant, and lactating queens and kittens as young as 8 weeks.

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37 of 46 people found this answer helpful

Can cats become immune to Frontline, thereby making it ineffective?

Like a lot of products, it is possible that the Frontline Plus For Cats could become ineffective if used repeatedly for a long period of time

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8 of 11 people found this answer helpful

Where is Frontline Plus For Cats made?

Frontline Plus For Cats is made by a global company called Merial and their headquarters are located in Duluth, GA.

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7 of 12 people found this answer helpful

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Frontline Plus For Cats 5 out of 5 stars Rating: 5 (2 Reviews / 12 Q&A)

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