Prairie dogs can be very difficult to control. A combination of trapping and barrier creation can be used. Other methods of control may be approved for use in your area, depending on where you are located. Since other burrowing animals will often inhabit old prairie dog tunnels, you will want to confirm what kind of animal is living in the burrows before you treat any burrows directly. You should contact your local animal control or Co-operative Extension office for the treatment methods that are allowed and most successful in your area.