INDICATIONS

Cattle: For the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs (note insert precautions), sucking lice, and mange mites in cattle.

Gastrointestinal Roundworms (adults and fourth-stage larvae):

• Ostertagia ostertagi (including inhibited O. ostertagi)
• O. lyrata
• Haemonchus placei
• Trichostrongylus axei
• T. colubriformis
• Cooperia oncophora
• C. punctata
• C. pectinata
• Oesophagostomum radiatum
• Bunostomum phlebotomum
• Nematodirus helvetianus (adults only)
• N. spathiger (adults only)

Lungworms (adults and fourth-stage larvae):

• Dictyocaulus viviparus

Cattle Grubs (parasitic stages):

• Hypoderma bovis
• H. lineatum

Sucking Lice:

• Linognathus vituli
• Haematopinus eurysternus
• Solenopotes capillatus

Mites (scabies):

• Psoroptes ovis (syn. P. communis var. bovis)
• Sarcoptes scabiei var. bovis

Persistent Activity

Ivermectin Injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days after treatment; Ostertagia ostertagi, Trichostrongylus axei and Cooperia punctata for 21 days after treatment; Haemonchus placei and Cooperia oncophora for 14 days after treatment.

Swine: Ivermectin Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, lice, and mange mites in swine:

Gastrointestinal Roundworms:

• Large roundworm, Ascaris suum
• (adults and fourth-stage larvae)
• Red stomach worm, Hyostrongylus rubidus
• (adults and fourth-stage larvae)
• Nodular worm, Oesophagostomum spp.
• (adults and fourth-stage larvae)
• Threadworm, Strongyloides ransomi (adults)

Somatic Roundworm Larvae:

• Threadworm, Strongyloides ransomi (somatic larvae)
• Sows must be treated at least seven days before farrowing to prevent infection in piglets.

Lungworms:

• Metastrongylus spp. (adults)

Lice:

• Haematopinus suis

Mange Mites:

• Sarcoptes scabiei var. suis

DOSAGE

Cattle: Ivermectin Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of Ivermectin Injection contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site).

• 220 lb = 2 ml
• 330 lb = 3 ml
• 440 lb = 4 ml
• 550 lb = 5 ml
• 660 lb = 6 ml
• 770 lb = 7 ml
• 880 lb = 8 ml
• 990 lb = 9 ml
• 1100 = 10 ml

Swine: Ivermectin Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of Ivermectin Injection contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight.

• Growing Pigs
  • 19 lb = 1/4 ml
  • 38 lb = 1/2 ml
  • 75 lb = 1 ml
  • 150 lb = 2 ml
• Breeding Animals (Sows, Gilts, and Boars)
  • ?225 lb = 3 ml
  • 300 lb = 4 ml
  • 375 lb = 5 ml
  • 450 lb = 6 ml

ADMINISTRATION

Cattle: Ivermectin Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16-gauge, ½ to ¾” needle is suggested. Inject under the loose skin in front of or behind the shoulder.

When using the 50 mL, 250 mL or 500 mL package size, use only automatic syringe equipment. Use sterile equipment and sanitize the injection site by applying a suitable disinfectant.

Clean, properly disinfected needles should be used to reduce the potential for injection site infections. No special handling or protective clothing is necessary.

Swine: Ivermectin (ivermectin) Injection is to be given subcutaneously in the neck. Animals should be appropriately restrained to achieve the proper route of administration. Use of a 16- or 18- gauge needle is suggested for sows and boars, while an 18- or 20- gauge needle may be appropriate for young animals. Inject under the skin, immediately behind the ear.

When using the 50 mL, 250 mL or 500 mL package size, use only automatic syringe equipment. As with any injection, sterile equipment should be used. The injection site should be cleaned and disinfected with alcohol before injection. The rubber stopper should also be disinfected with alcohol to prevent contamination of the contents. Mild and transient pain reactions may be seen in some swine following subcutaneous administration.

Recommended Treatment Program

Swine: At the time of initiating any parasite control program, it is important to treat all breeding animals in the herd. After the initial treatment, use Ivermectin Injection regularly as follows:

BREEDING ANIMALS

• Sows: Treat prior to farrowing, preferably 7-14 days before, to minimize infection of piglets
• Gilts: Treat 7-14 days prior to breeding
  • Treat 7-14 days prior to farrowing.
• Boars: Frequency and need for treatments are dependent upon exposure. Treat at least two times a year.

FEEDER PIGS

(Weaners/Growers/Finishers)

• All weaner/feeder pigs should be treated before placement in clean quarters.
• Pigs exposed to contaminated soil or pasture may need retreatment if reinfection occurs.

Environmental Safety

Studies indicate that when ivermectin comes in contact with soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain aquatic organisms on which they feed. Do not permit water runoff from feedlots or production sites to enter lakes, streams or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration.

As with other avermectins, Ivermectin is excreted in the dung of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction. The magnitude and duration of such effects are species and life-cycle specific. When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependant insects.